D. melanogaster gene Actin 5C , abbreviated as Act5C , is reported here . It has also been known in FlyBase as anon-EST:fe2D2, anon-fe2D2, l(1)G0009, l(1)G0010, l(1)G0025, l(1)G0079, l(1)G0117, l(1)G0177, l(1)G0245, l(1)G0330, l(1)G0420 and l(1)G0486. It encodes a product with putative structural constituent of cytoskeleton involved in sperm individualization which is a component of the actin filament ; it is expressed in the embryo (anterior embryonic/larval midgut , embryonic central nervous system , posterior embryonic/larval midgut , subesophageal ganglion and 2 other listed tissues). It has been sequenced and its amino acid sequence is also available. It has been mapped cytologically to 5C7 . There are 35 recorded alleles : 12 in vitro constructs ( 1 available from the public stock centers), 22 classical mutants ( 2 available from the public stock centers) and 1 wild-type. Mutations have been isolated which are larval lethal. Act5C is discussed in 174 references (excluding sequence accessions), dated between 1980 and 2004. These include at least 3 studies of mutant phenotypes , 3 studies of wild-type function , one study of natural polymorphisms and 12 molecular studies . Among findings on Act5C function, Act5C has a role in the individualization during spermatogenesis.
