|
Alphabetical list of genes |
Genes A - B - C - D - -- [Genes E-K -- Genes L-R -- Genes S-Z ]
- A
- abdominal-A
-
homeodomain transcription factor - Antp class - involved in subdivision of the visceral mesoderm
- Abdominal-B
-
homeodomain transcription factor - bithorax complex - required to specify the posterior abdomen and the genitalia
- Abl oncogene
-
non receptor tyrosine kinase with SH2 and SH3 domains - involved in axon extension
- abnormal chemosensory jump 6 (common alternative name: Ipou)
-
transcription factor - homeodomain and POU domain - determines odorant response profile of subsets of olfactory neurons
- abnormal spindle
-
microtubule binding protein - required for the integrity of microtubule organizing centers - may organize microtubules during cytokinesis
- abrupt
-
transcription factor - zinc finger BTB domain - controls the specificity of neuromuscular connections
- absent MD neurons and olfactory sensilla
-
proneural - required for the identity of a class of multidendritic neurons and for a class of olfactory sensilla
- absent, small, or homeotic discs 1
-
histone methyl transferase that indirectly prevents gene silencing - provides a specific signal for establishment of active transcription
- abstrakt
-
DEAD-box subfamily ATP-dependent helicase protein - involved in post-transcriptional regulation effecting synaptic function
- and axon outgrowth and fasciculation
- and axon outgrowth and fasciculation
- achaete
-
transcription factor - basic HLH - proneural - involved in the determination of the neural fate
- achintya
-
homeodomain transcription factor (TGIF subclass) - required, along with homeodomain protein Vismay, for spermatogenesis
- act up (preferred name: capulet)
-
cyclase-associate protein homolog - required to prevent actin filament polymerization in the eye disc
- alpha-Adaptin
- necessary for the formation of clathrin-coated pits and participates in the dynamin-dependent release of coated vesicles from the membrane surface as a prelude to vesicle recycling - acts downstream of Numb in the determination of alternative cell fates in asymmetric cell division
- Adar
-
double-stranded RNA adenosine deaminase - RNA editing enzyme that affects nervous system function, integrity, and behavior
- Adenomatous polypopsis coli tumor suppressor homolog 2
-
signaling protein in Wingless pathway and affects cytoskeletal regulation
- Adh transcription factor 1 (common alternative name: Nalyot)
-
transcription factor - Myb helix-turn-helix family involved in terminal stages of neuronal differentiation and function
- adrift
-
novel protein involved in tracheal branching
- A kinase anchor protein 200
-
Involved in Protein kinase A localization - PKA in turn regulates the function of specialized actin structures during oogenesis
- Akt1
-
S/T kinase with Src homology 2 domain - promotes cell survival - component of insulin pathway
- always early
- regulator of chromatin structure - a 'meiotic arrest' gene required for transcription of key G2-M cell cycle control genes and of spermatid differentiation genes
- amalgam
-
IG superfamily - ligand for Neurotactin - maintains proper cohesion between axons and contributes to the organization of fascicles
- amnesiac
-
pacap-like neuropeptide that activates the cAMP pathway stimulating learning and memory
- Amphiphysin
-
SH3 domain protein that functions in membrane morphogenesis - involved in cellularization and plays a role in establisment of proper localization of postsynaptic proteins
- beta amyloid protein precursor-like
-
beta amyloid homolog - contributes to synapse formation, maintenance, and plasticity
- anachronism
-
secreted glial glycoprotein that inhibits premature neuroblast proliferation
- Antennapedia
-
homeodomain transcription factor - Antp class - initiator of a cascade of events that result in the development of an adult leg
- anterior open (common alternative names: pokkuri or yan)
-
ets domain transcription factor - target of Ras pathway that serves to inhibit neural and other types of differentiation
- AP-2
-
transcription factor that plays essential roles in leg and proboscis outgrowth -
- involved in development of the adult brain central complex
- involved in development of the adult brain central complex
- Apaf-1-related-killer
-
CED-4 domain protein that links mitochondrial events to activation of caspases during programmed cell death
- APC-like
-
adenomatous polyposis coli homolog involved in the wingless pathway - functions in neural development
- apontic
-
novel bZIP transcription factor and RNA-binding protein - multi-functional protein involved in translational regulation
- and organ development
- and organ development
- aproctous (preferred name: brachyenteron)
-
transcription factor - brachyury homolog - mediates specification of caudal visceral mesoderm
- apterous
-
transcription factor - homeodomain - lim domain - involved in boundary formation in the developing wing
- araucan
-
transcription factor - homeodomain Pbx class - establishes a prepattern that determines the size, shape and number
- of sensory organ mother cells in imaginal discs
- of sensory organ mother cells in imaginal discs
- arc
-
PDZ domain protein involved in structuring epithelia
- archipelago
- F box component of an SCF-ubiquitin ligase - negatively regulates the levels and activity of Drosophila Myc by linking Myc
- to a protein degradation pathway - also negatively regulates Cyclin E and Notch
- to a protein degradation pathway - also negatively regulates Cyclin E and Notch
- Argonaute 1
-
PAZ domain protein involved in post-transcriptional gene silencing - mutants exhibit defects in the embryonic nervous system
- argos
-
ligand for Egf receptor - inhibitor of Egfr activation
- aristaless
-
transcription factor - homeodomain - paired-like - involved in the ontogeny of specific head segments and
- the initiation of appendage development
- the initiation of appendage development
- armadillo
-
plakoglobin and beta catenin homolog - functions in transducing signals from the Wingless/Wnt family of proteins
- and works with cadherins to mediate cell adhesion
- and works with cadherins to mediate cell adhesion
- armitage
- RNA helicase involved in posttranscriptional gene silencing - mutations disrupt mRNA translational silencing of oskar in the oocyte
- and silencing of Stellate in male germ cells
- and silencing of Stellate in male germ cells
- arrest
-
ribonucleoprotein-type RNA-binding protein - regulates multiple mRNAs involved in female and male gametogenesis -
- posterior group gene involved in assembly of the pole plasm
- posterior group gene involved in assembly of the pole plasm
- arrow
-
LDL-receptor-related protein (LRP) family - Wingless pathway - binds Axins and consequently induces LEF-1 activation
- by destabilizing Axin and stabilizing ß-catenin
- by destabilizing Axin and stabilizing ß-catenin
- Arrowhead
-
LIM domains and LIM homeodomain - requirement for proliferation of histoblast and imaginal ring tissue
- asense
-
basic HLH transcription factor - detected in neural precursors and their progeny but is not expressed in proneural clusters -
- participates in the allocation of the sensory mother cells that give rise to the bristles of the anterior wing margin
- participates in the allocation of the sensory mother cells that give rise to the bristles of the anterior wing margin
- ATM (preferred name: telomere fusion)
-
Phosphatidylinositol 3- and 4-kinase - Serves as Drosophila's ATM (ataxia telangiectasia mutated) - plays a conserved and essential role in the maintenance of normal telomeres and chromosome stability
- atonal
-
transcription factor - basic HLH -proneural gene that governs the development of chordotonal organs (stretch receptors in the body wall and joints) and as auditory organs in the antennae
- ATP-utilizing chromatin assembly and remodeling factor
-
PHD finger motifs and chromodomain - involved in chromatin assembly
- aubergine
- related to eukaryotic translation initiation factor 2C - involved in post-transcriptional gene silencing
- aurora (alternative name: aurora A)
- kinase required for centrosome separation - functions in asymmetric protein localization during mitosis
- aurora B (preferred name: IplI-aurora-like kinase)
- signaling protein involved in chromatin condensation during mitosis
- Axin
-
scaffolding protein - wingless pathway component
B
- baboon
-
transmembrane protein - Type 1 activin-A-receptor - essential for proper pupation and adult viability
- bag of marbles
-
novel protein involved in oogenesis and spermatogenesis
- bagpipe
-
transcription factor - homeodomain - NK-2 class - forms visceral mesoderm that differentiates into gut musculature
- bantam
-
a 21 nucleotide microRNA that promotes tissue growth, stimulates cell proliferation and prevents apoptosis
- BarH1 & BarH2
-
transcription factor - homeodomain - neural selector genes involved in the development of the external sensilli
- basket
-
MAP kinase homolog - Jun amino terminal kinase - involved in a pathway that regulates cell shape changes during dorsal closure
- bazooka
-
PAR-3 homolog, PDZ domain protein involved in cell polarity and asymmetric cell division
- Beadex (common alternative name: Lim-only (LMO)
-
LIM-only protein - functions to regulate Apterous activity levels
- Bearded
-
proneural - basic amphipathic alpha-helix - novel effector or modulator of Notch signaling
- beaten path
-
secreted - Ig superfamily - required for subsets of motor axons to correctly defasciculate from other motor axons
- at specific choice points
- at specific choice points
- bereft
-
potentially an untranslated RNA - mutants exhibit defects in the peripheral nervous system
- bicoid
-
transcription factor - homeodomain - maternally transcribed gene involved in anterior patterning of the Drosophila embryo
- Bicaudal-D
-
alpha helical coiled coiled protein that interacts with the cytoskeleton - regulates developmental fate of the the oocyte
- bifocal
- codes for a novel protein that interacts with f-actin - functions downstream of misshapen to reorganize the actin cytoskeleton
- big brain
-
aquaporin - MIP family signature - neurogenic gene that functions outside of the Notch pathway
- biniou
-
fork head domain transcription factor essential for maintaining the distinction between splanchnic and somatic mesoderm
- and for differentiation of the splanchnic mesoderm into midgut musculature
- and for differentiation of the splanchnic mesoderm into midgut musculature
- blistered (common alternative name: Serum response factor)
-
transcription factor - MADS-box motif - required for vein/intervein formation in the fly wing
- blistery
- tensin homolog - at focal adhesion sites participates in a protein complex that establishes transmembrane linkage between the extracellular matrix and cytoskeletal actin filaments
- Boss (symbol for bride of sevenless)
-
transmembrane ligand for sevenless - regulates determination of R7 photoreceptor fate
- boule
-
RRM motif protein involved in spermatogenesis
- brachyenteron
-
transcription factor - brachyury homolog - required for specification of hindgut and anal pads
- brahma
-
transcription factor - SWI2/SNF2 homolog - overcomes the repressive effect of chromatin to activate gene transcription
- brainiac
-
novel protein - secreted - oogenesis and EGF-R signaling - helps maintain epithelial structures
- brain tumor
-
involved in post-transcriptional regulation of Hunchback mRNA
- brakeless (preferred name: scribbler)
-
novel protein with a single zinc finger - multifunctional protein that regulates foraging activity and
- shapes the activity gradient of Dpp through regulation of thickveins
- shapes the activity gradient of Dpp through regulation of thickveins
- branchless
-
fibroblast growth factor homolog - ligand for Breathless
- breathless
-
transmembrane receptor, FGF-receptor homolog - used in the development of the trachea,
- and later plays a role in migration of specific midline glia and the resultant effect on axonogenesis
- and later plays a role in migration of specific midline glia and the resultant effect on axonogenesis
- bric à brac
-
transcription factor bearing a BTB/POZ domain - required for pattern formation along the proximal-distal axis of the leg and antenna
- Bride of sevenless (common alternative name: Boss)
-
transmembrane - ligand of sevenless - 7 TM segments - regulates determination of R7 photoreceptor fate
- brinker
-
novel transcription factor bearing weak homology to homeobox domain proteins - negatively regulates decapentaplegic target genes
- broad (common alternative name: Broad Complex)
-
transcription factor - zinc finger - BTD domain - a key regulator of gene activity at the onset of metamorphosis in Drosophila
- bruno (preferred name: arrest)
-
ribonucleoprotein-type RNA-binding protein - regulates multiple mRNAs involved in female and male gametogenesis
- Bub1
- protein serine/threonine kinase - mitotic checkpoint control protein - inhibits ubiquitin ligase activity of anaphase promoting complex (APC) preventing mitosis
- until all chromosomes are correctly attached to the mitotic spindle
- until all chromosomes are correctly attached to the mitotic spindle
- Buffy
- pro-survival homolog of the apoptosis regulator Bcl-2 - also regulates cell cycle
- bunched (common alternative name: shortsighted)
-
transcription factor - leucine zipper - regulates Dpp signaling pathway
- bursicon
-
neuropeptide hormone that controls cuticle sclerotization and wing expansion behavior
- buttonhead
-
transcription factor - zinc finger - transcriptonal activator that regulates the segmentation of the head
- buttonless
-
transcription factor - homeodomain - regulates the identity of the dorsal median cells that are arranged
- as a single pair within each segment along the dorsal midline just above the central nervous system
C
- as a single pair within each segment along the dorsal midline just above the central nervous system
- cacophony
- voltage sensitive calcium channel that stimulates neurotransmetter release at the presynaptic terminus at the neuromuscular junction
- cactus
-
signaling protein - IkappaB homolog - regulates the nuclear transport of Dorsal
- Cadherin-E (preferred name: Shotgun)
-
cadherin - regulates cell aggregation preventing mixing of cells at tissue boundaries
- Cadherin-N
-
cadherin - cell aggregation - regulates axon pathfinding
- Calcineurin (preferred name: Protein phosphatase 2B at 14D)
-
Calcium-dependent protein serine/threonine phosphatase - negatively regulates Egf receptor signaling
- Calcium/calmodulin-dependent protein kinase II
-
CaM kinase II - ATP binding motif - coordinates cellular responses to neurotransmitters and hormones -
- effects behavior and learning
- effects behavior and learning
- Calmodulin
-
calcium ion binding signaling protein - regulation of cellular processes dependent on Ca2+
- cAMP-dependent protein kinase 1 common alternative name: Protein kinase A (PKA)
-
catalytic subunit of PKA - involved in Hedgehog signaling pathway and functions in learning in the adult
- canoe
-
glgf/dhr motif scaffolding protein - interacts with genes in both the Notch and the Ras pathways
- capicua
-
transcription factor - HMG box protein - acts as a repressor of tailless and huckebein
- in both the anterior and posterior domains of the early Drosophila embryo
- in both the anterior and posterior domains of the early Drosophila embryo
- cap'n'collar
-
transcription factor - basic leucine zipper - involved in the segmentation of the head -
- effects both labral and mandibular structures
- effects both labral and mandibular structures
- capricious
- leucine-rich repeat transmembrane protein involved in selective synapse formation;
- contributes to formation of the affinity boundary between dorsal and ventral compartments of the wing
- contributes to formation of the affinity boundary between dorsal and ventral compartments of the wing
- capulet (common alternative name: act up)
-
cyclase-associate protein homolog - sequesters monomeric actin - required to prevent
- actin filament polymerization in the eye disc
- actin filament polymerization in the eye disc
- Cardioacceleratory peptide
- a neuropeptide - controls behavior during molting
- Casein kinase II alpha subunit and beta subunit
-
CkII catalytic and regulatory subunits - modulates Antennapedia's properties, restricting its activity to an appropriate level
- Caspase 1 (preferred name: Death caspase-1)
-
ICE/CED-3 protease - regulates developmental apoptosis or programmed cell death
- castor (common alternative name: ming)
-
transcription factor - zinc finger - regulates the development of late CNS sublineages
- caudal
-
transcription factor - homeodomain - plays a role in establishing the posterior domains of the embryo, which give rise to the posterior gut
- caupolican
-
transcription factor - homeodomain Pbx class - a prepattern gene that determines the size, shape and
- number of sensory organ mother cells in imaginal discs
- number of sensory organ mother cells in imaginal discs
- Cbl
-
ubiquitin ligase - positively regulates receptor tyrosine ubiquitination accelerating degradation of ligand-receptor complexes
- cdc2
-
a cdc2 kinase - heterdimerizes with cyclin A and cyclin B - responsible for the execution of the mitotic (M) phase of the cell cycle
- cdc42
-
a Ras type GTPase - involved in epithelial cell elongation - facilitates nucleation of actin filaments
- Cdc27 (common alternative name makos)
- subunit of anaphase-promoting complex (APC) - involved in regulating cell cycle
- chk2 (preferred name: loki)
-
homolog of mammalian Chk2 - a serine/threonine kinase required
required for DNA damage-mediated cell cycle arrest and apoptosis
- centromere identifier
- a variant of histone H3 - localizes exclusively to centromeres - chromatin component that plays a key role in assembling the kinetochore at meiosis and mitosis
- chickadee
-
profilin homolog - regulates polymerization of the actin cytoskeleton
- chico
-
insulin receptor substrate family - the major cytoplasmic substrate of the insulin receptor
- chiffon
-
Dbf4 homolog - regulatory subunit of Cdc7-Dbf4 dimer - interacts with unknown regulators and
- activates the kinase function of its dimerization partner, thus triggering the initiation of cellular DNA replication
- activates the kinase function of its dimerization partner, thus triggering the initiation of cellular DNA replication
- Chip
-
transcription factor - enhancer facilitator - functions at enhancers to bring together diverse transcriptional factors and
- form higher order activation complexes; or, in some cases, it may block formation of such complexes
- form higher order activation complexes; or, in some cases, it may block formation of such complexes
- Chromatin assembly factor 1 subunit
-
A histone chaperone protein - mediates nucleosome assembly on both the leading and lagging strands
- immediately after passage of the DNA replication fork
- immediately after passage of the DNA replication fork
- chromosome bows (common alternative names: Orbit and Mast)
- microtubule-associated protein that plays an essential role facilitating the kinetochore-microtubule interaction -
- maternially it facilitates multiple interactions of the fusome with mitotic spindles and ring canals -
- zygotically it mediates the action of Slit and its receptors acting as a partner of the Abelson tyrosine kinase
- maternially it facilitates multiple interactions of the fusome with mitotic spindles and ring canals -
- clift (common alternative name: eyes absent)
-
novel protein - eyes absent family - cell survival factor - functions in eye development
- and in the embryonic determination of the somatic gonadal precursor cell fate
- and in the embryonic determination of the somatic gonadal precursor cell fate
- Clock
-
transcription factor - bHLH and PAS domains - regulates circadian rhythms
- clueless (preferred name: abrupt)
-
transcription factor - zinc finger BTB domain - controls the muscle expression of molecules required for correct motorneuron targeting
- collier (preferred name: knot)
-
EBF/Olf-1 homolog, HLH protein - required for the formation of the hypopharyngeal lobe,
- the proper development of the larval head skeleton, and suppresses vein formation between veins 3 and 4,
- the proper development of the larval head skeleton, and suppresses vein formation between veins 3 and 4,
- comatose
-
N-ethylmaleimide-sensitive fusion (NSF) gene - required in disassembly or rearrangement of the SNARE complex at the plasma membrane after vesicule fusion
- combgap
-
zinc finger transcription factor - involved in pattern formation and the regulation of cell fate
- commissureless
-
novel transmembrane protein - involved in axon pathfinding and neuromuscular synaptogenesis
- Connectin
-
Leucine rich repeat homophilic cell adhesion protein expressed in a subset of muscles and the motoneurons that innervate them
- COP9 complex homolog subunit 5
- Component of COP9 signalsome - regulates ubiquitin-dependent protein degradation - Jab1/MPN domain metalloenzyme motif
- coracle
-
protein 4.1 homolog - links transmembrane proteins to cytoskeleton
- corkscrew
-
protein tyrosine phosphatase - SH2 domains - downregulates receptor tyrosine kinase signaling
- Cortactin
-
cytoskeletal component that acts as a link, via Src, between surface receptors and actin - interacts with F-actin and can stimulate actin polymerization by direct interaction with the Arp2/3 complex
- costa (common alternative name: costal2)
-
kinesin like protein - hedgehog signaling - a cytoplasmic anchor for Cubitus interruptus
- courtless
- ubiquitin conjugation enzyme - plays a role in protein degradation - mutation disrupts early steps of courtship behavior in Drosophila males and the development of their sperm
- cousin of atonal
-
bHLH transcription factor required for sensory neuron morphology
- cramped
-
a novel Polycomb group protein - physically interacts with Proliferating cell nuclear antigen,
- a protein involved in DNA replication and repair
- a protein involved in DNA replication and repair
- CrebB-17A
-
transcription factor - cAMP response element binding protein - acts downstream of Protein kinase A - regulates genes involved
- in learning and memory
- in learning and memory
- CREB-binding protein (preferred name: nejire)
-
CBP, a transcriptional co-activator that interacts with
- a large number of developmentally important transcription factors
- a large number of developmentally important transcription factors
- crocodile
-
winged helix, forkhead family - establishing the domains of expression for wingless and engrailed in the clypeolabrum,
- the anterior most segment of the fly's head
- the anterior most segment of the fly's head
- crooked legs
-
multiple zinc finger transcription factor - mutants exhibit both a morphological defect in leg morphogenesis
- and altered gene expression during morphogenesis
- and altered gene expression during morphogenesis
- crossveinless 2
-
chordin-like cysteine rich domain protein: modifies BMP signaling
- crumbs
-
transmembrane - egf repeats - laminin A homolog - involved in epithelial polarity
- cryptochrome
-
potential transcription factor - light response protein - cryptochrome/photolyase
- C-terminal binding protein
-
transcription factor-interacting protein - a transcriptional co-repressor
- cubitus interruptus
-
transcription factor - zinc finger - mediates Hedgehog signaling
- Cullin1 (preferred name: lin-19-like)
-
a major component of a series of multimeric ubiquitin ligases that control the degradation of a broad range of proteins
- cup
- translational repressor - represses oskar translation - physically interacts with Bruno
- cut
-
transcription factor - homeodomain - cut domain - mediates choice between chordotonal sense organ
- and external sensory organ fate - also involved in wing and follicle cell morphogenesis
- and external sensory organ fate - also involved in wing and follicle cell morphogenesis
- Cyclic-AMP response element binding protein A
-
basic leucine zipper transcription factor - required for patterning cuticular structures on both dorsal and ventral surfaces
- Cyclin A
-
a a G2-M phase cyclin - cell cycle regulator - dimerization partner of cdc2 kinase
- Cyclin B
-
a G2-M phase cyclin - cell cycle regulator - dimerization partner of cdc2 kinase
- Cyclin D
-
cell cycle regulator - a G1-S phase cyclin
- Cyclin-dependent kinase 4/6
-
a Cdk involved in control of growth of cells - partners cyclin D - governs progression through the G1 phase of the cell cycle
- Cyclin-dependent kinase 5
-
a Cdk involved in control of cell differentiation and morphology
- Cyclin-dependent kinase 7
-
a Cdk-activating kinase and general transcription factor - required for the activation of both Cdc2/Cyclin A and
- Cdc2/Cyclin B complexes, and for cell division
- Cdc2/Cyclin B complexes, and for cell division
- Cyclin-dependent kinase 9
-
subunit of P-TEFb, targets RNA polymerase II
- Cyclin E
-
a G1-S phase cyclin - dimerization partner of cdc2c kinase
- Cyclin J
-
regulates S phase early in embryonic development, partners Cdk2
D
- dacapo
-
cyclin dependent kinase inhibitor - inhibits cell cycle progression
- dachsous
-
cadherin superfamily - controls imaginal disc morphogenesis
- dachshund
-
transcriptional co-repressor - required for elongation of leg discs
- daughterless
-
transcription factor - basic HLH - proneural gene that is also involved in sex determination
- daughter of sevenless
-
an adaptor protein that facilitates signal transduction as a downstream component of the receptor tyrosine kinases Sevenless, Egf receptor and Torso
- Daughters against dpp
-
Smad family - inhibits Dpp signal transduction
- DC0
-
Protein kinase A catalytic subunit - a signal transduction protein involved in learning and memory and in the Hedgehog pathway
- dCREB2 (preferred name: CrebB-17A)
-
transcription factor - basic leucine zipper - acts downstream of Protein kinase A -
- regulates genes involved in learning and memory
- regulates genes involved in learning and memory
- deadpan
-
transcription factor - bHLH - hairy/E(spl) class - a pan-neural repressor
- dead ringer
-
transcription factor - ARID domain protein - required for proper patterning of the abdomen
- Death caspase-1
-
ICE/CED-3 protease involved in apoptosis
- death executioner Bcl-2 homologue
-
Bcl-2/CED-9 family protein involved in regulating apoptosis
- Death related ced-3/Nedd2-like protein
-
ICE/CED-3 protease involved in apoptosis
- DE-cadherin (preferred name: shotgun)
-
transmembrane - E-cadherin homolog - cell adhesion - sets up boundaries between epithelial compartments preventing cell mixing
- decapentaplegic
-
ligand - tgf-beta homolog - early on dpp establishes embryonic dorsal/ventral --
- later defines boundaries between appendage compartments
- later defines boundaries between appendage compartments
- defective proventriculus
-
homeodomain transcription factor - involved in the establishment of two gut structures:
- the proventriculus (a foregut structure) and the central midgut
- the proventriculus (a foregut structure) and the central midgut
- Deformed
-
transcription factor - homeodomain - Antp class - required to form a normal head -
- involved in establishing the form of the maxillary and mandibular segments
- involved in establishing the form of the maxillary and mandibular segments
- Delta
-
transmembrane - EGF family - Notch ligand - important in establishing neural cell fates
- deltex
-
docking molecule - binds Notch regulating Notch signaling
- DER (Preferred name: EGF-R) (common alternative name: Torpedo)
-
transmembrane receptor- tk - EGF-R homology - during oogenesis helps set up egg polarity, determines the identity of cells in the ectoderm;
- during larval stages participates in the development of the eye and wing.
- ventral ectoderm; during larval stages participates in the development of the eye and wing.
- during larval stages participates in the development of the eye and wing.
- derailed
-
receptor tyrosine kinase - functions in axon during central nervous system and brain development
- DFR-1 (preferred name: Heartless - also commonly known as Fibroblast growth factor receptor 1)
-
receptor tyrosine kinase - involved in the development of mesodermal and neuronal cells
- DHR3 (preferred name: Hormone receptor-like/Hr46)
-
transcription factor - nuclear receptor superfamily - a second tier regulator involved in Drosophila molting --
- acts negatively on Ecdysone receptor and postively on genes expressed subsequently in the molting hierarchy
- acts negatively on Ecdysone receptor and postively on genes expressed subsequently in the molting hierarchy
- diaphanous
-
Formin homology domain protein required for cytokinesis
- Dicer-1
- ribonuclease III family, double-stranded RNA domain binding domain, DEAD/DEAH box helicase, PAZ domain -
- an enzyme involved in degrading RNA - involved in double-stranded RNA interference (RNAi) and post-transcriptional gene regulation (PTGS)
- an enzyme involved in degrading RNA - involved in double-stranded RNA interference (RNAi) and post-transcriptional gene regulation (PTGS)
- Dichaete (preferred name: Sox box protein 70D, common alternative name: fish-hook)
-
HMG-domain protein - SOX-domain protein - implicated in the regulation of pair-rule genes
- and later functions in wing morphogenesis
- and later functions in wing morphogenesis
- diego
-
ankyrin repeat protein involved in tissue polarity - helps promote polarized clustering of Flamingo
- diminutive (common alternative name: dmyc)
-
bHLH - leucine zipper - controls cell cycle progression
- dimmed (common alternative name: Mist 1-related)
-
Atonal family bHLH transcription factor - component of a mechanism by which diverse neuroendocrine lineages
- differentiate and maintain a pro-secretory state
- differentiate and maintain a pro-secretory state
- Disabled
-
novel signaling protein - interacts with Abl to regulate axon guidance
- disc proliferation abnormal
-
Licensing factor - Zn finger motif - cdc21 homolog - MCM4 homolog - implicated in the initiation of DNA replication
- and in the discrimination between replicated and unreplicated chromatin
- and in the discrimination between replicated and unreplicated chromatin
- discs overgrown (common alternative name: double-time)
-
casein kinase Iepsilon - contributes to circadian rhythmicity
- discs large 1
-
Links septate junctions to cytoskeleton - Guanylate kinase signature and Src homology 3 domain
- discs lost
-
conserved protein of unknown function - required for cell survival and cell cycle progression - implicated in modification of olfactory behavior
- dishevelled
-
novel cytoplasmic protein - a component in the wingless pathway and regulates epithelial polarity
- dispatched
-
patched family protein regulating Hedgehog release
- dissatisfaction
-
nuclear receptor superfamily - essential for many aspects of sexual behavior and neural development in both males and females
- distal antenna & distal antenna-related
-
two closely linked genes coding for pipsqueak domain proteins - effector genes that act downstream of homothorax and Distal-less
- to control differentiation of distal antennal structures
- to control differentiation of distal antennal structures
- Distal-less
-
transcription factor - homeodomain - defines the termini of appendages and regulates appendage growth
- division abnormally delayed
-
membrane bound glypican related proteoglycan - effects cell division of lamina precursor cells of the optic lobe
- DJun (Preferred name: Jun-related antigen)
-
transcription factor - basic leucine zipper - cooperates with the ETS domain protein Pointed to induce R7 fate in the developing eye
- Dlar (preferred name: Leukocyte-antigen-related-like)
-
transmembrane - receptor tyrosine kinase functioning to regulate axon guidance
- dmyc (preferred name: diminutive)
-
bHLH - leucine zipper - controls cell cycle progression
- dodo
-
peptidylprolyl isomerase - facilitates the degradation of the transcription factor CF2, which regulates expression of the rhomboid gene in follicle cells
- domeless
-
a divergent member of the cytokine class I receptor family - required for segmentation and functions in trachea specification
- Domina
-
forkhead/winged-helix class - a suppressor of position effect variegation that also affects and regulates eye and bristle development
- dorsal
-
transcription factor - NFkappaB/rel homolog - functions in establishment of dorsal/ventral polarity
- Dorsal related immune factor
-
NFkappaB/rel homolog - a regulator of the immune response
- Dorsocross
-
three closely linked T-box domain transcription factors that are crucial for completion of differentiation,
- cell proliferation arrest, and survival of amnioserosa cells
- cell proliferation arrest, and survival of amnioserosa cells
- double parked
-
conserved protein required for DNA replication
- doublesex
-
novel zinc finger transcription factor - regulates sexual differentiation of both sexes
- double-time (preferred name: discs overgrown)
-
casein kinase Iepsilon - contributes to circadian rhythmicity
- dreadlocks
-
SH2 and SH3 domain signal transduction protein - required for photoreceptor cell growth cone guidance and targeting
- drifter (preferred name: ventral veins lacking)
-
transcription factor - homeodomain - pou domain - mutants display severe tracheal defects and defects in ventral midline glia migration
- Dronc (preferred name: Nedd2-like caspase)
-
cysteine protease - a functional homolog of CED-3/caspase-9 - involved in programmed cell death
- Dror
-
receptor tyrosine kinase - trk homolog - expressed during neural differentiation
- dtfr (preferred name: thickveins)
-
receptor of Decapentaplegic
- Dscam
-
multiple Ig domain protein - acts with other proteins to direct pathfinding of Bolwig's nerve
- dunce
-
cyclic AMP phosphodiesterase - involved in memory and learning
- Dynein heavy chain 64C
-
a molecular motor - functions in axon transport
- dysfusion
- bHLH-PAS protein expressed in tracheal fusion cells and required for tracheal fusion
- Dystroglycan
-
transmembrane receptor for extracellular matrix molecules - required for cellular polarity in epithelial cells and the oocyte
Genes E-K -- Genes L-R -- Genes S-Z
Home page: The Interactive Fly© 1995, 1996 Thomas B. Brody, Ph.D.
Please e-mail comments/corrections to brodyt@codon.nih.gov
FlyBase-NG uses Argos: A Replicable Genome infOrmation System